MicroRNA clustering on the biogenesis of suboptimal microRNAs

Abstract Most microRNAs (miRNAs) are processed by two ribonuclease III enzymes. The first cleavage is performed Microprocessor that composed of RNase enzyme Drosha and DGCR8, the second another Dicer. There many examples miRNAs poor substrates for Dicer, owing to their suboptimal structures. However, a number these known be expressed at same or higher level as neighboring structurally-optimal miRNAs. Recent studies suggest clustered orientation explanation this phenomenon. It has been observed biogenesis can affected expression optimal This principle expected apply more broadly, it shown large percentage reside within operons.